{"id":3623,"date":"2023-10-10T14:51:20","date_gmt":"2023-10-10T17:51:20","guid":{"rendered":"https:\/\/fundaciondaya.org\/mystaging01\/?p=3623"},"modified":"2023-10-10T14:51:53","modified_gmt":"2023-10-10T17:51:53","slug":"modular-el-sistema-endocannabinoide-sii","status":"publish","type":"post","link":"https:\/\/fundaciondaya.org\/mystaging01\/modular-el-sistema-endocannabinoide-sii\/","title":{"rendered":"Modular el Sistema Endocannabinoide como forma de tratar el S\u00edndrome de Intestino Irritable\/ Paper"},"content":{"rendered":"
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S\u00edndrome del intestino irritable: Modulaci\u00f3n del sistema endocannabinoide como tratamiento de primera l\u00ednea<\/h2>\n<\/div>\n<\/div>\n<\/div>\n

Introducci\u00f3n<\/p>\n

El s\u00edndrome del intestino irritable (SII) es un trastorno funcional caracterizado por dolor abdominal, espasmos y deposiciones alteradas, ya sea predominantemente diarrea (SII-D) o predominantemente estre\u00f1imiento (SII-E), o alternando entre esos estados (Saha, 2014). . En el mundo occidental afecta entre el 10 y el 15% de la poblaci\u00f3n (Canavan et al., 2014). El SII representa una hipersensibilidad visceral, con caracter\u00edsticas de alodinia e hiperalgesia gastrointestinal (GI). Considerada una afecci\u00f3n que dura toda la vida, est\u00e1 claro que las agresiones gastrointestinales importantes, como la intoxicaci\u00f3n alimentaria o la administraci\u00f3n de antibi\u00f3ticos, pueden generar ataques que persisten, a menudo indefinidamente. Las agresiones se asocian con ansiedad y depresi\u00f3n, pero contin\u00faa la controversia sobre cu\u00e1l incita al otro (Saha, 2014). Es posible que algunos pacientes desarrollen un c\u00edrculo vicioso de empeoramiento de los s\u00edntomas f\u00edsicos y psicol\u00f3gicos (Jones et al., 2013, 2017).<\/p>\n

Actualmente, a los pacientes con SII se les recetan opioides, anticolin\u00e9rgicos y antidepresivos, aunque con resultados bastante sub\u00f3ptimos. Se han formulado otros compuestos para interactuar con los circuitos serotonin\u00e9rgicos, sin embargo, estos han sido retirados de ciertos mercados debido a su asociaci\u00f3n con colitis isqu\u00e9mica (alosetr\u00f3n, cilansetr\u00f3n) y eventos cardiovasculares (tegaserod), dejando, de facto, una necesidad cl\u00ednica urgente (Ford et al. ., 2014; Lexicomp Online, 2017).<\/p>\n

Se sabe que el Sistema Endocannabinoide (ECS) modula varias funciones, incluido el estado de \u00e1nimo, la ansiedad y la recuperaci\u00f3n de la memoria de eventos traum\u00e1ticos, y coordina directamente la propulsi\u00f3n, secreci\u00f3n, inflamaci\u00f3n y nocicepci\u00f3n gastrointestinal, lo que proporciona una justificaci\u00f3n para los agentes capaces de interactuar con el ECS como candidatos a tratamiento para el SII (Russo, 2016).<\/p>\n

Descarga el Paper<\/h2>\n

https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2020.00371\/full\u00a0<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

S\u00edndrome del intestino irritable: Modulaci\u00f3n del sistema endocannabinoide como tratamiento de primera l\u00ednea Introducci\u00f3n El s\u00edndrome del intestino irritable (SII) es un trastorno funcional caracterizado por dolor abdominal, espasmos y deposiciones alteradas, ya sea predominantemente diarrea (SII-D) o predominantemente estre\u00f1imiento (SII-E), o alternando entre esos estados (Saha, 2014). . En el mundo occidental afecta entre […]<\/p>\n","protected":false},"author":9,"featured_media":3629,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","ub_ctt_via":"","_themeisle_gutenberg_block_has_review":false,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[129],"tags":[],"class_list":["post-3623","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-estudios"],"featured_image_src":"https:\/\/i0.wp.com\/fundaciondaya.org\/mystaging01\/wp-content\/uploads\/2023\/10\/1-Titulo.jpg?fit=1080%2C1080&ssl=1","author_info":{"display_name":"Felipe Herrera","author_link":"https:\/\/fundaciondaya.org\/mystaging01\/author\/felipe_herrera\/"},"yoast_head":"\nModular el Sistema Endocannabinoide como forma de tratar el S\u00edndrome de Intestino Irritable\/ Paper - Fundaci\u00f3n Daya<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modular el Sistema Endocannabinoide como forma de tratar el S\u00edndrome de Intestino Irritable\/ Paper\" \/>\n<meta property=\"og:description\" content=\"S\u00edndrome del intestino irritable: Modulaci\u00f3n del sistema endocannabinoide como tratamiento de primera l\u00ednea Introducci\u00f3n El s\u00edndrome del intestino irritable (SII) es un trastorno funcional caracterizado por dolor abdominal, espasmos y deposiciones alteradas, ya sea predominantemente diarrea (SII-D) o predominantemente estre\u00f1imiento (SII-E), o alternando entre esos estados (Saha, 2014). . 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